My research combines high-throughput genome sequencing, phenotyping, transcriptomics, quantitative trait loci (QTLs) mapping and genetic association analyses to understand the genetic basis of functionally relevant and industrially important traits. The aim of my research is to generate knowledge and develop technology to aid the application of yeasts in food and industrial biotechnology.
I am also interested in understanding the role of non-coding RNA in cell function and gene regulation and studying the mechanisms required for evolutionary adaptations of organisms to environmental change.
I believe in integrating research and teaching activities as it builds up the knowledge transfer process and prepares students to be lifelong learners. Previously, while teaching undergraduate field courses at the University of Manchester, I developed studies on the biodiversity of microorganisms at Alpine environments which lead to the discovery of novel yeast species.
Professional memberships and activities
- Microbiology Society
- American Society for Microbiology
- Genetics Society of America
- European Society for Evolutionary Biology
- PhD. 2011. ‘Molecular evolution in yeast: Role of chromosomal inversions and translocations in speciation, adaptation and gene expression processes.’ The University of Manchester, UK.
- MSc. 2007. Microbiology. University of Karachi, Pakistan
- BSc (Hons). 2006. Microbiology. University of Karachi, Pakistan.
- Molecular Biology and Microbiology
- Yeast Genetics and Biotechnology
- Synthetic Biology
- Isolation of microbial species from natural environments
- Applying synthetic biology and quantitative genetics to study yeast hybrids for biotechnological purposes.
- Study the role of chromosomal rearrangements on fitness adaptation and global gene expression.
- Understanding the role of non-coding RNA in cell function and gene regulation.
- Determining the environmental factors affecting the microbial biodiversity and understanding their physiological and evolutionary adaptation.
- Molecular Genetics and Genetic Engineering
- Research projects
- Hewitt SK, Duangrattanalert K, Burgis T, Zeef L, Naseeb S, and Delneri D. Plasticity of mitochondrial DNA inheritance and its impact on nuclear gene transcription in yeast hybrids. Microorganisms. Mar 31;8(4). pii: E494
- Alsammar HF, Naseeb S, Brancia LB, Gilman RT, Wang P and Delneri D. Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments. Environmental microbiology reports. 11(2):206-214.
- Naseeb S, Alsammar H, Burgis T, Donaldson I, Knyazev N, Knight C, and Delneri D. Whole genome sequencing, de novoassembly and phenotypic profiling for the new budding yeast species Saccharomyces jurei. G3: Genes, Genomes, Genetics. 2018. 8(9):2967-2977.
- Fraczek MG, Naseeb S and Delneri D. History of genome editing in yeast. Yeast. 35(5):361-368.
- Naseeb S, Ames RM, Delneri D and Lovell SC. Rapid functional and evolutionary changes follow gene duplication in Yeast. Proceedings of the Royal Society B. 284: 20171393.
- Naseeb S, James SA, Alsammar H, Michaels CJ, Gini B, Nueno-Palop C, Bond CJ, McGhie H, Roberts NI, and Delneri D. Saccharomyces jurei nov., Isolation and genetic Identification of a novel yeast species from Quercus robur. International Journal of Systematic and Evolutionary Microbiology. 2017. 67: 2046-2052. (Press release by the University of Manchester media (https://www.manchester.ac.uk/discover/news/new-species-of-yeast-could-help-beer-brewers-reach-new-heights/) and by Quadram Institute, Norwich, 2017; https://quadram.ac.uk/new-species-yeast-discovered-head-heights/).
- Naseeb S, Carter Z, Minnis D, Donaldson I, Zeef L and Delneri D. Widespread impact of chromosomal inversions on gene expression uncovers robustness via phenotypic buffering. Molecular Biology and Evolution. 2016. 33(7): 1679–1696.
- Hooks KB*, Naseeb S*, Parker S, Griffiths-Jones S and Delneri D. Novel intronic RNA structures contribute to maintenance of phenotype in Saccharomyces cerevisiae. 2016. 203(3): 1469-81. (*Equal contributions) (highlighted by Starr B. in New & Noteworthy, Saccharomyces Genome Database, 2016; https://www.yeastgenome.org/blog/keep-only-what-you-need).
- Naseeb S, Sohail M, Ahmed A and Khan SA. Production of xylanases and cellulases by Aspergillus fumigatus MS16 using crude lignocellulosic substrates. Pakistan Journal of Bot 2015. 47(2): 779-784.
- Piatkowska EM, Naseeb S, Knight D, and Delneri D. Chimeric protein complexes in hybrid species generate novel phenotypes. PLoS Genetics. 2013. 9(10): e1003836. (highlighted by Stower H., in Nature Reviews Genetics, Vol 14; https://www.nature.com/articles/nrg3617).
- Naseeb S and Delneri D. Impact of chromosomal inversions on yeast DAL cluster. PLoS One. 7(8): e42022.
For full publication list see the below google scholar link: