Dr Arthur Hosie

Job Title and Responsibilities

Senior Lecturer in Biological and Biomedical Sciences (Microbiology)
Biological Safety Officer

About Me

I am an experienced research scientist and higher education lecturer with an interest in molecular microbiology.

 My interest in molecular microbiology began during my undergraduate education at The University of Glasgow. I first applied this knowledge at Moredun Research Institute in Edinburgh, where I worked for three years on the animal pathogen, Mycobacterium avium ssp. paratuberculosis, which is associated with Johne's disease in ruminants. Having become certain that I would like to continue a career in academia, I returned to The University of Glasgow to carry out a PhD research project investigating the production of sodium channel blocking toxins by heterotrophic marine bacteria. I then worked with Professor Philip Poole as a BBSRC funded postdoctoral research fellow at the University of Reading, where I investigated amino acid uptake by ABC transporters in rhizobia.
 
My first lecturer post was at King's College London, in the Dental Institute, where I supervised a number of PhD students investigating the molecular biology of key dental pathogens, including Streptococcus mutans and Tannerella forsythia. In 2010, I moved to the University of Bedfordshire as Senior Lecturer in Microbiology. Although this academic role was more focused on teaching undergraduate and postgraduate students, I continued to research the molecular biology of a range of pathogenic bacteria, including Staphylococcus aureus
 
In January 2018, I moved to the School of Life Sciences and Education at Staffordshire University as Senior Lecturer in Microbiology. I am responsible for coordinating research in the Department of Biological Sciences, including PG research students: I am the PGR tutor. In June 2019 I was appointed as the Biological Safety Officer for Staffordshire University, a role I fulfil alongside my academic responsibilities.

Qualifications

PhD (University of Glasgow, 1998)
BSc (Hons) Microbiology (University of Glasgow, 1991)
Postgraduate Certificate in Academic Practice (KCL, 2005)

Professional Memberships and Activities

  • Higher Education Academy (Fellow; from 2005)

  • Microbiology Society

  • Society for Applied Microbiology

Expertise

  • Molecular microbiology

  • Bacterial pathogenesis and virulence factors

  • Post-genomic microbiology

  • ATP binding cassette (ABC) transport proteins in bacteria

 

Research Interests

The aim of my research is to better understand bacterial physiology and pathogenesis by exploiting microbial genome sequence data and molecular techniques.

A principal interest is the function and mechanism of action of transport proteins involved in pathogenesis. Such transporters are promising targets for novel antimicrobial strategies - as vaccine components or drug targets. Furthermore, their central role dictates that the results from such investigations will illuminate our understanding of wider aspects of microbial physiology and pathogenesis.

Selected Publications

S Basavanna, S Chimalapati, A Maqbool, B Rubbo, J Yuste, RJ Wilson, A Hosie, AD Ogunniyi, JC Paton, G Thomas, JS Brown (2013) The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence. PLOS One8 (1): e49638. Doi:10.1371/journal.pone.0049638.

J Prell, A Bourdes. S Kumar, S Lodwig, A Hosie, S Kinghorn, J White, P Poole (2010) Role of symbiotic auxotrophy in Rhizobium-legume symbioses. PLOS One5 (11): e13933. doi:10.1371/ journal.pone.0013933.

E Severi, AHF Hosie, J Hawkhead, GH Thomas (2010) Characterisation of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters. FEMS Microbiology Letters304 47-54.

S Basavanna, S Khandavilli, J Yuste, JM Cohen, AHF Hosie, AJ Webb, GH Thomas, JS Brown (2009) Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched chain amino acid ABC transporter, is necessary for disease pathogenesis. Infection and Immunity77 (8), 3412-3423. 

H Thompson, KA Homer, S Rao, V Booth, AHF Hosie, (2009) An orthologue of Bacteroides fragilis NanH is the principal sialidase in Tannerella forsythia. Journal of Bacteriology191 (11) 3263-3628.

AJ Webb, KA Homer, AHF Hosie (2008) Two closely related ABC transporters in Streptococcus mutans are involved in di/oligosaccharide uptake. Journal of Bacteriology190 (1) 168-178.

AJ Webb, KA Homer, AHF Hosie (2007) A phosphoenolpyruvate-dependent phosphotransferase system is the principal maltose transporter in Streptococcus mutans. Journal of Bacteriology189 3322-3327.

E Allan, H Hussain, S Miah, ZK Ascott, MH Khwaja and AHF Hosie (2007) Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus mutans. FEMS Microbiology Letters268 47-51.

TH Mauchline, JE Fowler, AK East, AL Sartor, R Zaheer, AHF Hosie, PS Poole & TM Finan (2006) Mapping the Sinorhizobium meliloti 1021 solute binding protein-dependent transportome. Proceedings of the National Academy of Sciences103 17933-17938.

A Webb and AHF Hosie (2006) A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans. Journal of Bacteriology188 8005-8012.

EM Lodwig*, AHF Hosie*, A Bourd├Ęs, K Findlay, D Allaway, R Karunakaran, JA Downie and PS Poole (2003) Amino-acid cycling drives nitrogen fixation in the legume-Rhizobium symbiosis. Nature422 722-725.
(*These authors contributed equally to this work)

AHF Hosie, D Allaway, and PS Poole (2002) A monocarboxylate permease of Rhizobium leguminosarum is the first member of a new subfamily of transporters. Journal of Bacteriology184 5436-5448.

AHF Hosie, D Allaway, HA Dunsby, CS Galloway, and PS Poole (2002) Rhizobium leguminosarum has a second general amino acid permease with unusually broad substrate specificity and high similarity to branched-chain amino acid transporters (Bra/LIV) of the ABC family. Journal of Bacteriology184 4071-4080.

AHF Hosie, D Allaway, MA Jones, DL Walshaw, AWB Johnston and PS Poole (2001) Solute-binding protein-dependent ABC transporters are responsible for solute efflux in addition to solute uptake. Molecular Microbiology40 1449-1459.
Further publication details are available here: https://orcid.org/0000-0002-1327-7901

Current Teaching

Level 4
Structure and function (on-campus & blended learning)
Biology of Disease (on-campus & blended learning)
Level 5
Microbiology (module coordinator)
Infection Science (on-campus & blended learning: module coordinator)
Professional practice and placement
Level 6
Human Infectious Disease (module coordinator)
Research project
Level 7
Infectious disease (distance learning; module coordinator)
Molecular Diagnostics

Contact

Dr Arthur Hosie
Department of Biological Sciences,
School of Life Sciences and Education,
Staffordshire University,
Science Centre,
Leek Road,
Stoke-on-Trent,
ST4 2DF
t: +44 (0)1782 294611
e: Arthur.hosie@staffs.ac.uk