My research interests focus on the roles mitochondria play in aspects of eukaryotic life, ranging from their origin, metabolism, biogenesis and role they play in cell death pathways. These are interrogated using biochemical, molecular biology, genetic and cell biology techniques. I incorporate these interests into classes I teach to provide an understanding of practical techniques and also the current literature in the field. I am also a strong supporter of scientific communications and outreach to disseminate scientific developments and knowledge to a broader audience with the goal of increasing the general support of the scientific process.
Ph.D., University of Bristol “Molecular characterisation of the mitochondrial permeability transition pore”, 2003
B.Sc., University of Leeds, Biochemistry with industrial placement, 1999
Professional Memberships and Activities
American Society for Biochemistry and Molecular Biology
American Society for Cell Biology
Genetics Society of America
New York Academy of Sciences
Mitochondrial physiology and cell death pathways in model systems using biochemical, molecular biology, genetic, and cell biology techniques.
Enterprise and Commercial ActivitiesDevelopment of machine learning based biomedical research abstract announcement services.
Current interests focus on the signalling pathways engaged during mitochondrial stress and also determining the consequences of caspase mutations identified from whole genome sequencing efforts.
- Ali, S, McStay GP. Regulation of mitochondrial dynamics by proteolytic processing and turnover. Antioxidants 7 (1): 15, 2018.
- McStay GP. Turnover of mitochondrial transporters and ion channels. Journal of Bioenergetics and Biomembranes 49 (1): 101-111, 2017.
- McStay GP. Use of peptide-based substrates and inhibitors of apoptotic caspases. Methods in Molecular Biology 1419: 57-67, 2016.
- Su C-H, McStay GP, Tzagoloff A. Assembly of the Rotor Component of Yeast Mitochondrial ATP Synthase is Enhanced when Atp9p is Supplied by Atp9p-Cox6p Complexes. Journal of Biological Chemistry 289 (45): 31605-31616, 2014.
- McStay GP, Green DR. Measuring Apoptosis: Caspase Inhibitors and Activity Assays. Cold Spring Harbor Protocols 2014 (8): 799-806, 2014.
- Su C-H, McStay GP, Tzagoloff A. The Cox3p Assembly Module of Yeast Cytochrome Oxidase. Molecular Biology of the Cell 25 (7): 965-976, 2014.
Undergraduatemodules team member:
Bioscience concepts and practice;
Building blocks of life;
Professional practice and placement;
Postgraduate modules team member:
ContactGavin P. McStay, Ph.D.
Department of Biological Sciences,
School of Life Sciences and Education,
R115 Science Centre,
t: +44 (0)1782 295741