Gavin P. McStay, Ph.D.

Role

Senior Lecturer

About Me

My research interests focus on the roles mitochondria play in aspects of eukaryotic life, ranging from their origin, metabolism, biogenesis and role they play in cell death pathways.  These are interrogated using biochemical, molecular biology, genetic and cell biology techniques.  I incorporate these interests into classes I teach to provide an understanding of practical techniques and also the current literature in the field.  I am also a strong supporter of scientific communications and outreach to disseminate scientific developments and knowledge to a broader audience with the goal of increasing the general support of the scientific process. 

 

Qualifications

Ph.D., University of Bristol “Molecular characterisation of the mitochondrial permeability transition pore”, 2003
B.Sc., University of Leeds, Biochemistry with industrial placement, 1999

Professional Memberships and Activities

American Society for Biochemistry and Molecular Biology
American Society for Cell Biology
Genetics Society of America

Microbiology Society
New York Academy of Sciences

 

Expertise

Mitochondrial physiology and cell death pathways in model systems using biochemical, molecular biology, genetic, and cell biology techniques.

Enterprise and Commercial Activities

Development of machine learning based biomedical research abstract announcement services. 

Research Interests

Current interests focus on the signalling pathways engaged during mitochondrial stress and also determining the consequences of caspase mutations identified from whole genome sequencing efforts. 

Selected Publications

  • Ali, S, McStay GP. Regulation of mitochondrial dynamics by proteolytic processing and turnover.  Antioxidants 7 (1): 15, 2018.  
  • McStay GP.  Turnover of mitochondrial transporters and ion channels.  Journal of Bioenergetics and Biomembranes 49 (1): 101-111, 2017. 
  • McStay GP.  Use of peptide-based substrates and inhibitors of apoptotic caspases.  Methods in Molecular Biology 1419: 57-67, 2016.
  • Su C-H, McStay GP, Tzagoloff A.  Assembly of the Rotor Component of Yeast Mitochondrial ATP Synthase is Enhanced when Atp9p is Supplied by Atp9p-Cox6p Complexes.  Journal of Biological Chemistry 289 (45): 31605-31616, 2014. 
  • McStay GP, Green DR.  Measuring Apoptosis: Caspase Inhibitors and Activity Assays. Cold Spring Harbor Protocols 2014 (8): 799-806, 2014.
  • Su C-H, McStay GP, Tzagoloff A.  The Cox3p Assembly Module of Yeast Cytochrome Oxidase. Molecular Biology of the Cell 25 (7): 965-976, 2014. 

Current Teaching

Undergraduatemodules team member:

  • Bioscience concepts and practice;

  • Building blocks of life;

  • Professional practice and placement;

  • Research project

Postgraduate modules team member:

  • Molecular diagnostics


 

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Contact

Gavin P. McStay, Ph.D.
Senior Lecturer,
Department of Biological Sciences,
School of Life Sciences and Education,
R115 Science Centre,
Staffordshire University,
Leek Road,
Stoke-on-Trent,
ST4 2DF
t: +44 (0)1782 295741
e: gavin.mcstay@staffs.ac.uk