Dr Willian Da Silveira

Lecturer

Health, Education, Policing and Sciences

I’m a Lecturer in Molecular Genetics and Genomics with a background on Bioinformatics and Pharmacy/Biochemistry. I am a co-coordinator of the Topical Team in Space Omics funded by the European Space Agency and a Visiting Lecturer at the International Space University.

I wanted to be a scientist since I was a child. I entered college at 19 and the next year I started an internship in Biochemistry, followed by internships in Biophysics and Immunology. I then did a Master Degree in Biosciences applied to Pharmacy and then PhD in Medical Sciences where I worked with the transcriptomics of Breast Cancer Stem Cells. Where I did a 1 year internship at the Montpellier Cancer Research Centre, in France.

Finishing my PhD I worked for 3 years at the Centre for Genomic Medicine at the Medical University of South Carolina, during this period I joined the NASA Genelab analysis working groups. In 2019 I moved to work on Food System Biology at the Queen’s University Belfast, in Northern Ireland. In the beginning of 2021 I was hired by Staffordshire University.

Professional memberships and activities

Member of NASA Genelab Analysis Working Groups (Systems Biology / Multi-Omics Analysis; Animal, RNA-Seq Technical Working Group), USA.
Co-Head for Multi-omics and System Biology of the European Space Agency Topical Team for Space Omics. ESA. International Organization.
Associate Fellow of the Higher Education Academy
Adjunct Lecturer of the International Space University

Academic qualifications

NASA STAR’s Training Program Certificate of Completion. NASA, USA.
Associate Fellow of the Higher Education Academy - AFHEA. Fellowship reference PR203494.
Ph.D. degree in Medical Sciences, University of São Paulo. Brazil.
Master Degree in Biosciences applied to Pharmaceutical Sciences (Distinction). University of São Paulo. Brazil.
Bachelor's degree in Pharmacy-Biochemistry (First-Class Honours). University of São Paulo. Brazil.

Expertise

System Biology
Multi-omics
Ageing
Space Biology
Cancer

Research interests

System Biology
Multi-omics
Ageing
Space Biology
Cancer

Teaching

Undergraduate

Level 04 Developing Research and Professional identity - BIOL40679

Level 06 Genomics and Bioinformatics - BIOL60668

Postgraduate

Level 07 Bioinformatics - BIOL70651

Level 07 Research Project Proposal - BIOL70674

Publications

Selected Publications:

Willian A. da Silveira, Hossein Fazelinia, Sara Brin Rosenthal, Evagelia C. Laiakis, Man S Kim, Cem Meydan, Yared Kidane, Komal S. Rathi, Scott M. Smith, Benjamin Stear, Yue Ying, Yuanchao Zhang, Jonathan Foox, Susana Zanello, Brian Crucian, Dong Wang, Adrienne Nugent, Helio A. Costa, Sara R. Zwart, Sonja Schrepfer, R. A. Leo Elworth, Nicolae Sapoval, Todd Treangen, Jonathan C. Schisler, Matthew MacKay, Nandan S. Gokhale, Stacy M. Horner, Larry N. Singh, Douglas C. Wallace, Jeffrey S. Willey, Robert Meller, J. Tyson McDonald, Kathleen M. Fisch, Gary Hardiman, Deanne Taylor, Christopher E. Mason, Sylvain V. Costes, Afshin Beheshti. Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020 Nov 25;183(5):1185-1201.e20. doi: 10.1016/j.cell.2020.11.002.

Pedro Madrigal, Alexander Gabel, Alicia Villacampa, Aranzazu Manzano, Colleen S. Deane, Daniela Bezdan, Eugénie Carnero-Diaz, F. Javier Medina, Gary Hardiman, Ivo Grosse, Nathaniel Szewczyk, Silvio Weging, Stefania Giacomello, Stephen Harridge, Tessa Morris-Paterson, Thomas Cahill, Willian A. da Silveira, Raúl Herranz. Revamping Space-omics in Europe. Cell Syst. 2020 Nov 9:S2405-4712(20)30413-0. doi: 10.1016/j.cels.2020.10.006.

Willian Abraham da Silveira, Esteban Vazquez-Hidalgo, Elesha Bartolotta, Ludivine Renaud, Paul Paolini & Gary Hardiman. The effects of Rosiglitazone on the neonatal rat cardiomyocyte transcriptome – A temporal analysis. Pharmacogenomics. 2019 Nov;20(16):1125-1141. doi:10.2217/pgs-2019-0077.

Overbey EG*, da Silveira WA*, Stanbouly S, Nishiyama NC, Roque-Torres GD, Pecaut MJ, Zawieja DC, Wang C, Willey JS, Delp MD, Hardiman G, Mao XW. Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress related damage in the murine retina. Sci Rep. 2019 Sep 16;9(1):13304. doi: 10.1038/s41598-019-49453-x. *both authors contributed equally.

Willian A. da Silveira, E. Starr Hazard, Dongjun Chung, and Gary Hardiman. Molecular Profiling of RNA Tumors Using High-Throughput RNA Sequencing: From Raw Data to Systems Level Analyses. Sarah S. Murray (ed.), Tumor Profiling: Methods and Protocols, Methods in Molecular Biology, vol. 1908, https://doi.org/10.1007/978-1-4939-9004-7_13.

da Silveira WA, Renaud L, Simpson J, Glen WB Jr, Hazard ES, Chung D, Hardiman G. miRmapper: A Tool for Interpretation of miRNA-mRNA Interaction Networks. Genes (Basel). 2018 Sep 14;9(9). pii: E458. doi: 10.3390/genes9090458.

da Silveira WA, Palma PVB, Sicchieri RD, Villacis RAR, Mandarano LRM, Oliveira, TMG, Antonio HMR, Andrade JM, Muglia VF, Rogatto SR, Theillet C, du Manoir S,Tiezzi DG. Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype. Sci Rep. 2017 Jun 6;7(1):2851. doi: 10.1038/s41598-017-02761-6.

willian.dasilveira@staffs.ac.uk